Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50148908
Substrate
n/a
Meas. Tech.
ChEBML_51104
Ki
150±n/a nM
Citation
 Chen, C; Wilcoxen, KM; Huang, CQ; McCarthy, JR; Chen, T; Grigoriadis, DE Optimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility. Bioorg Med Chem Lett 14:3669-73 (2004) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50148908
Synonyms:
CHEMBL123306 | Cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-5-methanesulfonyl-2-methyl-3H-pyrazolo[1,5-a]pyrimidin-7-yl]-propyl-amine
Type:
Small organic molecule
Emp. Form.:
C21H24Cl2N4O2S
Mol. Mass.:
467.412
SMILES:
CCCN(CC1CC1)c1cc(nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl)S(C)(=O)=O |(13.26,-5.31,;13.23,-6.85,;14.54,-7.65,;14.49,-9.18,;15.81,-9.99,;15.77,-11.53,;17.08,-12.33,;14.67,-12.61,;13.14,-9.93,;13.09,-11.46,;11.74,-12.2,;10.41,-11.4,;10.46,-9.83,;9.37,-8.77,;10.04,-7.39,;9.3,-6.03,;11.56,-7.6,;11.84,-9.12,;7.85,-9.05,;7.34,-10.5,;5.83,-10.76,;4.82,-9.59,;3.33,-9.98,;5.35,-8.14,;6.87,-7.86,;7.62,-6.53,;11.69,-13.73,;11.28,-15.22,;10.34,-14.47,;13,-14.55,)|
Structure:
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