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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50092485
Substrate
n/a
Meas. Tech.
ChEMBL_205065 (CHEMBL810259)
IC50
5.8±n/a nM
Citation
 Occhiato, EG; Ferrali, A; Menchi, G; Guarna, A; Danza, G; Comerci, A; Mancina, R; Serio, M; Garotta, G; Cavalli, A; De Vivo, M; Recanatini, M Synthesis, biological activity, and three-dimensional quantitative structure-activity relationship model for a series of benzo[c]quinolizin-3-ones, nonsteroidal inhibitors of human steroid 5alpha-reductase 1. J Med Chem 47:3546-60 (2004) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Human
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50092485
Synonyms:
4-methyl-8-chloro-1,2,5,6-tetrahydro pyrido[1,2-a]quinolin-3-one | 8-Chloro-4-methyl-1,2,5,6-tetrahydro-pyrido[1,2-a]quinolin-3-one | CHEMBL118446
Type:
Small organic molecule
Emp. Form.:
C14H14ClNO
Mol. Mass.:
247.72
SMILES:
CC1=C2CCc3cc(Cl)ccc3N2CCC1=O |c:1|
Structure:
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