Reaction Details Report a problem with these data
Target
Small conductance calcium-activated potassium channel protein 2
Ligand
BDBM50583197
Substrate
n/a
Meas. Tech.
ChEMBL_2156785 (CHEMBL5041445)
EC50
>100000±n/a nM
Citation
El-Sayed, NS; Nam, YW; Egorova, PA; Nguyen, HM; Orfali, R; Rahman, MA; Yang, G; Wulff, H; Bezprozvanny, I; Parang, K; Zhang, M Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of K J Med Chem 65:303-322 (2022) [PubMed] Article
More Info.:
Target
Name:
Small conductance calcium-activated potassium channel protein 2
Synonyms:
KCNN2_RAT | Kcnn2 | Small conductance calcium-activated potassium channel | Small conductance calcium-activated potassium channel protein 2 | Small conductance calcium-activated potassium channel protein 2 (KCa2.2)
Type:
Protein
Mol. Mass.:
63876.72
Organism:
Rattus norvegicus (Rat)
Description:
P70604
Residue:
580
Sequence:
MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
Inhibitor
Name:
BDBM50583197
Synonyms:
CHEMBL5079951
Type:
Small organic molecule
Emp. Form.:
C16H24N6
Mol. Mass.:
300.402
SMILES:
Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H]2CC[C@H](N)CC2)n1 |r,wD:14.14,17.18,(30.83,-10.14,;29.3,-10.3,;28.53,-11.64,;27.02,-11.32,;25.88,-12.35,;26.86,-9.79,;28.27,-9.16,;25.53,-9.03,;24.19,-9.8,;22.85,-9.03,;21.52,-9.8,;22.86,-7.48,;24.18,-6.71,;24.18,-5.17,;25.51,-4.4,;25.51,-2.86,;26.84,-2.08,;28.17,-2.85,;29.51,-2.08,;28.18,-4.39,;26.85,-5.16,;25.52,-7.48,)|