Reaction Details Report a problem with these data
Target
Histone deacetylase 11
Ligand
BDBM29589
Substrate
n/a
Meas. Tech.
ChEMBL_2159155 (CHEMBL5043905)
IC50
2.7±n/a nM
Citation
 Jiang, Y; Xu, J; Yue, K; Huang, C; Qin, M; Chi, D; Yu, Q; Zhu, Y; Hou, X; Xu, T; Li, M; Chou, CJ; Li, X Potent Hydrazide-Based HDAC Inhibitors with a Superior Pharmacokinetic Profile for Efficient Treatment of Acute Myeloid Leukemia In Vivo. J Med Chem 65:285-302 (2022) [PubMed]  Article 
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Human
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM29589
Synonyms:
Faridak | LBH-589 | LBH-589B | Panobinostat | US10722597, Compound Panobinostat
Type:
Small organic molecule
Emp. Form.:
C21H23N3O2
Mol. Mass.:
349.4262
SMILES:
Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
Structure:
Search PDB for entries with ligand similarity: