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Target
Estrogen receptor
Ligand
BDBM50154053
Substrate
n/a
Meas. Tech.
ChEMBL_306464 (CHEMBL829541)
IC50
1335±n/a nM
Citation
 Malamas, MS; Manas, ES; McDevitt, RE; Gunawan, I; Xu, ZB; Collini, MD; Miller, CP; Dinh, T; Henderson, RA; Keith, JC; Harris, HA Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem 47:5021-40 (2004) [PubMed]  Article 
Target
Name:
Estrogen receptor
Synonyms:
ESR1_MOUSE | Esr | Esr1 | Estr | Estra | Estrogen receptor alpha | Nr3a1
Type:
PROTEIN
Mol. Mass.:
66969.87
Organism:
Mus musculus
Description:
ChEMBL_648798
Residue:
599
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPTVFNYPEGAAYEFNAAAAAAAAASAPVYGQSGIAYGPGSEAAAFSANSLGAFPQLNSVSPSPLMLLHPPPQLSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGASGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEEPSQTQLATTSSTSAHSLQTYYIPPEAEGFPNTI
  
Inhibitor
Name:
BDBM50154053
Synonyms:
2-(4-Hydroxy-phenyl)-benzooxazol-6-ol | 2-(4-hydroxyphenyl)benzo[d]oxazol-6-ol | CHEMBL187673
Type:
Small organic molecule
Emp. Form.:
C13H9NO3
Mol. Mass.:
227.2155
SMILES:
Oc1ccc(cc1)-c1nc2ccc(O)cc2o1
Structure:
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