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Target
RNA-directed RNA polymerase
Ligand
BDBM50154444
Substrate
n/a
Meas. Tech.
ChEMBL_306663 (CHEMBL831436)
IC50
1000±n/a nM
Citation
 Summa, V; Petrocchi, A; Matassa, VG; Taliani, M; Laufer, R; De Francesco, R; Altamura, S; Pace, P HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis. J Med Chem 47:5336-9 (2004) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50154444
Synonyms:
2-(3-Benzyloxy-phenyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid | CHEMBL188307
Type:
Small organic molecule
Emp. Form.:
C18H14N2O5
Mol. Mass.:
338.3142
SMILES:
OC(=O)c1nc([nH]c(=O)c1O)-c1cccc(OCc2ccccc2)c1
Structure:
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