Reaction Details Report a problem with these data
Target
DNA-directed RNA polymerase subunit beta
Ligand
BDBM50155484
Substrate
n/a
Meas. Tech.
ChEMBL_306640 (CHEMBL832977)
IC50
1260±n/a nM
Citation
Doundoulakis, T; Xiang, AX; Lira, R; Agrios, KA; Webber, SE; Sisson, W; Aust, RM; Shah, AM; Showalter, RE; Appleman, JR; Simonsen, KB Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation. Bioorg Med Chem Lett 14:5667-72 (2004) [PubMed] Article
More Info.:
Target
Name:
DNA-directed RNA polymerase subunit beta
Synonyms:
Bacterial DNA-directed RNA polymerase | DNA-directed RNA polymerase beta chain | DNA-directed RNA polymerase subunit beta | RNA polymerase subunit beta | RNA polymerase subunit beta (β-RNAP) | RNAP subunit beta | RPOB_ECOLI | Transcriptase subunit beta | groN | nitB | rif | ron | rpoB | stl | stv | tabD
Type:
Enzyme
Mol. Mass.:
150595.80
Organism:
Escherichia coli (strain K12)
Description:
P0A8V2
Residue:
1342
Sequence:
MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAAFRSVFPIQSYSGNSELQYVSYRLGEPVFDVQECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKLPATIILRALNYTTEQILDLFFEKVIFEIRDNKLQMELVPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKDDVKLIEVPVEYIAGKVVAKDYIDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISETLRVDPTNDRLSALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLLREEIEGSGILSKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDTLMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRKVTDGVVTDEIHYLSAIEEGNYVIAQANSNLDEEGHFVEDLVTCRSKGESSLFSRDQVDYMDVSTQQVVSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMERAVAVDSGVTAVAKRGGVVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPCVSLGEPVERGDVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVSRDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLSEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKINPIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINAMLKQQQEVAKLREFIQRAYDLGADVRQKVDLSTFSDEEVMRLAENLRKGMPIATPVFDGAKEAEIKELLKLGDLPTSGQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMPESFNVLLKEIRSLGINIELEDE
Inhibitor
Name:
BDBM50155484
Synonyms:
CHEMBL185761 | CHEMBL186013 | CHEMBL186014 | {(E)-5-[5-((2E,4E)-2,5-Dimethyl-nona-2,4-dienoyl)-4-hydroxy-6-oxo-6H-pyran-2-yl]-hex-1-enyl}-carbamic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C24H33NO6
Mol. Mass.:
431.5219
SMILES:
CCCCC(C)=CC=C(C)C(=O)c1c(O)cc(oc1=O)C(C)CCCC=NC(=O)OC |w:26.27,7.6,4.4|