Reaction Details Report a problem with these data
Target
Cytochrome P450 2D6
Ligand
BDBM116257
Substrate
n/a
Meas. Tech.
ChEMBL_2169651 (CHEMBL5054710)
IC50
13400±n/a nM
Citation
Machauer, R; Lueoend, R; Hurth, K; Veenstra, SJ; Rueeger, H; Voegtle, M; Tintelnot-Blomley, M; Rondeau, JM; Jacobson, LH; Laue, G; Beltz, K; Neumann, U Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious ?-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease. J Med Chem 64:15262-15279 (2021) [PubMed] Article
More Info.:
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR