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Target
Histamine H1 receptor
Ligand
BDBM50160937
Substrate
n/a
Meas. Tech.
ChEMBL_305389 (CHEMBL833040)
IC50
86±n/a nM
Citation
 Fonquerna, S; Miralpeix, M; Pagès, L; Puig, C; Cardús, A; Antón, F; Vilella, D; Aparici, M; Prieto, J; Warrellow, G; Beleta, J; Ryder, H Synthesis and structure-activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H1 antagonists. Bioorg Med Chem Lett 15:1165-7 (2005) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
  
Inhibitor
Name:
BDBM50160937
Synonyms:
2-(2-{4-[1-(2-Ethoxy-ethyl)-1H-indol-3-yl]-piperidin-1-yl}-ethoxy)-benzaldehyde | CHEMBL184989
Type:
Small organic molecule
Emp. Form.:
C26H32N2O3
Mol. Mass.:
420.5439
SMILES:
CCOCCn1cc(C2CCN(CCOc3ccccc3C=O)CC2)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: