Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50161040
Substrate
n/a
Meas. Tech.
ChEMBL_306206 (CHEMBL830164)
IC50
9000±n/a nM
Citation
 Xin, Z; Zhao, H; Serby, MD; Liu, B; Schaefer, VG; Falls, DH; Kaszubska, W; Colins, CA; Sham, HL; Liu, G Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists. Bioorg Med Chem Lett 15:1201-4 (2005) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50161040
Synonyms:
3-(2,6-Dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (2-cyano-4-diethylamino-phenyl)-amide | CHEMBL362595
Type:
Small organic molecule
Emp. Form.:
C22H20Cl2N4O2
Mol. Mass.:
443.326
SMILES:
CCN(CC)c1ccc(NC(=O)c2c(C)onc2-c2c(Cl)cccc2Cl)c(c1)C#N |(6.64,2.87,;6.98,1.37,;5.86,.32,;6.21,-1.18,;7.71,-1.62,;4.37,.76,;3.97,2.26,;2.5,2.66,;1.41,1.58,;-.09,1.98,;-1.17,.88,;-.77,-.62,;-2.64,1.28,;-3.05,2.75,;-2.09,3.96,;-4.58,2.84,;-5.13,1.39,;-3.92,.42,;-3.85,-1.12,;-2.48,-1.82,;-.98,-2.2,;-2.38,-3.37,;-3.68,-4.19,;-5.06,-3.51,;-5.14,-1.97,;-6.52,-1.27,;1.82,.11,;3.32,-.29,;1.53,-1.19,;1.12,-2.88,)|
Structure:
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