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Target
Cytochrome P450 4A11
Ligand
BDBM50591501
Substrate
n/a
Meas. Tech.
ChEMBL_2200603 (CHEMBL5113119)
IC50
390±n/a nM
Citation
Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem 65:14599-14613 (2022) [PubMed]
More Info.:
Target
Name:
Cytochrome P450 4A11
Synonyms:
1.14.14.1 | 1.14.14.80 | 20-HETE synthase | 20-hydroxyeicosatetraenoic acid synthase | CP4AB_HUMAN | CYP4A11 | CYP4A2 | CYP4AII | CYPIVA11 | Cytochrome P-450HK-omega | Cytochrome P450 4A11 | Cytochrome P450HL-omega | Fatty acid omega-hydroxylase | Lauric acid omega-hydroxylase | Long-chain fatty acid omega-monooxygenase | Synonyms=CYP4A2
Type:
PROTEIN
Mol. Mass.:
59367.30
Organism:
Human
Description:
ChEMBL_119703
Residue:
519
Sequence:
MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL