Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM50592566
Substrate
n/a
Meas. Tech.
ChEMBL_2204519 (CHEMBL5117227)
IC50
135±n/a nM
Citation
 Ai, Y; Sakamuru, S; Imler, G; Xia, M; Xue, F Improving the solubility and antileukemia activity of Wnt/?-catenin signaling inhibitors by disrupting molecular planarity. Bioorg Med Chem 69:0 (2022) [PubMed] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM50592566
Synonyms:
CHEMBL5201325
Type:
Small organic molecule
Emp. Form.:
C21H18N4O
Mol. Mass.:
342.3938
SMILES:
Cc1nn(c(C)c1C(=O)Nc1ccc2ccccc2n1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: