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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50165872
Substrate
n/a
Meas. Tech.
ChEMBL_305410 (CHEMBL833059)
IC50
48±n/a nM
Citation
 Laughlin, SK; Clark, MP; Djung, JF; Golebiowski, A; Brugel, TA; Sabat, M; Bookland, RG; Laufersweiler, MJ; VanRens, JC; Townes, JA; De, B; Hsieh, LC; Xu, SC; Walter, RL; Mekel, MJ; Janusz, MJ The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production. Bioorg Med Chem Lett 15:2399-403 (2005) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50165872
Synonyms:
CHEMBL196369 | [4-(4-Fluoro-phenyl)-5-oxo-3-(2-phenoxy-pyrimidin-4-yl)-5H-isoxazol-2-yl]-acetaldehyde
Type:
Small organic molecule
Emp. Form.:
C21H14FN3O4
Mol. Mass.:
391.352
SMILES:
Fc1ccc(cc1)-c1c(-c2ccnc(Oc3ccccc3)n2)n(CC=O)oc1=O
Structure:
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