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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50172914
Substrate
n/a
Meas. Tech.
ChEMBL_321533 (CHEMBL880593)
IC50
0.9±n/a nM
Citation
 Charton, J; Cazenave Gassiot, A; Girault-Mizzi, S; Debreu-Fontaine, MA; Melnyk, P; Sergheraert, C Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective sigma1 ligands. Part 1. Bioorg Med Chem Lett 15:4833-7 (2005) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50172914
Synonyms:
(S)-2-(2-Piperidin-1-yl-ethyl)-3-thioxo-2,3,10,10a-tetrahydro-5H-imidazo[1,5-b]isoquinolin-1-one | CHEMBL193805
Type:
Small organic molecule
Emp. Form.:
C18H23N3OS
Mol. Mass.:
329.46
SMILES:
Oc1c2Cc3ccccc3Cn2c(=S)n1CCN1CCCCC1
Structure:
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