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Target
DNA helicase IV
Ligand
BDBM50177712
Substrate
n/a
Meas. Tech.
ChEMBL_334855 (CHEMBL871172)
IC50
7000±n/a nM
Citation
 Dubaele, S; Jahnke, W; Schoepfer, J; Fuchs, J; Chène, P Inhibition of DNA helicases with DNA-competitive inhibitors. Bioorg Med Chem Lett 16:923-7 (2006) [PubMed]  Article 
Target
Name:
DNA helicase IV
Synonyms:
HELD_ECOLI | Helicase IV | helD
Type:
PROTEIN
Mol. Mass.:
77988.86
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_334855
Residue:
684
Sequence:
MELKATTLGKRLAQHPYDRAVILNAGIKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFVLPDEKVVRLHGTEWGETQRFYHHLDAHWRRWSGEMSEIASGVLRQQLDLIATRTGENKWLTREQTSGVQQQIRQALSALPLPVNRLEEFDNCREAWRKCQAWLKDIESARLQHNQAYTEAMLTEYADFFRQVESSPLNPAQARAVVNGEHSLLVLAGAGSGKTSVLVARAGWLLARGEASPEQILLLAFGRKAAEEMDERIRERLHTEDITARTFHALALHIIQQGSKKVPIVSKLENDTAARHELFIAEWRKQCSEKKAQAKGWRQWLTEEMQWSVPEGNFWDDEKLQRRLASRLDRWVSLMRMHGGAQAEMIASAPEEIRDLFSKRIKLMAPLLKAWKGALKAENAVDFSGLIHQAIVILEKGRFISPWKHILVDEFQDISPQRAALLAALRKQNSQTTLFAVGDDWQAIYRFSGAQMSLTTAFHENFGEGERCDLDTTYRFNSRIGEVANRFIQQNPGQLKKPLNSLTNGDKKAVTLLDESQLDALLDKLSGYAKPEERILILARYHHMRPASLEKAATRWPKLQIDFMTIHASKGQQADYVIIVGLQEGSDGFPAAARESIMEEALLPPVEDFPDAEERRLMYVALTRARHRVWALFNKENPSPFVEILKNLDVPVARKP
  
Inhibitor
Name:
BDBM50177712
Synonyms:
(2-methyl-5-oxo-5,11-dihydro-10-thia-dibenzo[a,d]cyclohepten-7-yl)-acetic acid | CHEMBL201985
Type:
Small organic molecule
Emp. Form.:
C17H14O3S
Mol. Mass.:
298.356
SMILES:
Cc1ccc2c(CSc3ccc(CC(O)=O)cc3C2=O)c1
Structure:
Search PDB for entries with ligand similarity: