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Target
RuvB-like 2
Ligand
BDBM50600249
Substrate
n/a
Meas. Tech.
ChEMBL_2233419 (CHEMBL5147191)
IC50
>66000±n/a nM
Citation
 Zhang, G; Wang, F; Li, S; Cheng, KW; Zhu, Y; Huo, R; Abdukirim, E; Kang, G; Chou, TF Discovery of small-molecule inhibitors of RUVBL1/2 ATPase. Bioorg Med Chem 62:0 (2022) [PubMed] 
Target
Name:
RuvB-like 2
Synonyms:
3.6.4.12 | 48 kDa TATA box-binding protein-interacting protein | 48 kDa TBP-interacting protein | 51 kDa erythrocyte cytosolic protein | ECP-51 | INO80 complex subunit J | INO80J | RUVB2_HUMAN | RUVBL2 | Repressing pontin 52 | Reptin 52 | TAP54-beta | TIP48 | TIP49B | TIP60-associated protein 54-beta
Type:
PROTEIN
Mol. Mass.:
51149.94
Organism:
Homo sapiens
Description:
ChEMBL_104584
Residue:
463
Sequence:
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVLEMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALTQAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTTPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS
  
Inhibitor
Name:
BDBM50600249
Synonyms:
CHEMBL5204197
Type:
Small organic molecule
Emp. Form.:
C28H28F3N5O
Mol. Mass.:
507.55
SMILES:
Cc1ccc(Cc2c(C)nc3c(cnn3c2C)C(=O)N2CCN(CC2)c2ccc(cc2)C(F)(F)F)cc1
Structure:
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