Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM493757
Substrate
n/a
Meas. Tech.
ChEMBL_2234752 (CHEMBL5148524)
Ki
131±n/a nM
Citation
 Liu, S; Ding, W; Huang, W; Zhang, Z; Guo, Y; Zhang, Q; Wu, L; Li, Y; Qin, R; Li, J; Shi, T; Zhang, X; Lei, J; Hu, W Discovery of Novel Benzo[4,5]imidazo[1,2- J Med Chem 65:8933-8947 (2022) [PubMed] 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM493757
Synonyms:
US10988455, Example 1(xcv)
Type:
Small organic molecule
Emp. Form.:
C15H11ClFN5
Mol. Mass.:
315.733
SMILES:
Cc1cc(cc(Cl)n1)-c1nnc(N)nc1-c1ccc(F)cc1
Structure:
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