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Target
Alanine--glyoxylate aminotransferase
Ligand
BDBM50601020
Substrate
n/a
Meas. Tech.
ChEMBL_2235709 (CHEMBL5149481)
Ki
3500±n/a nM
Citation
 Grottelli, S; Annunziato, G; Pampalone, G; Pieroni, M; Dindo, M; Ferlenghi, F; Costantino, G; Cellini, B Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1. J Med Chem 65:9718-9734 (2022) [PubMed] 
Target
Name:
Alanine--glyoxylate aminotransferase
Synonyms:
2.6.1.44 | 2.6.1.51 | AGT | AGT1 | AGT1_HUMAN | AGXT | SPAT | SPT | Serine--pyruvate aminotransferase
Type:
PROTEIN
Mol. Mass.:
43020.00
Organism:
Human
Description:
ChEMBL_120660
Residue:
392
Sequence:
MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRAALQHCPKKKL
  
Inhibitor
Name:
BDBM50601020
Synonyms:
CHEMBL5183689
Type:
Small organic molecule
Emp. Form.:
C13H12FNO
Mol. Mass.:
217.2389
SMILES:
NOCc1cccc(c1)-c1ccc(F)cc1
Structure:
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