Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50183248
Substrate
n/a
Meas. Tech.
ChEMBL_349790 (CHEMBL866283)
IC50
3000±n/a nM
Citation
 Chen, J; Chang, HW; Kim, HP; Park, H Synthesis of phospholipase A2 inhibitory biflavonoids. Bioorg Med Chem Lett 16:2373-5 (2006) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50183248
Synonyms:
2-{4-[4-(4-oxo-4H-chromen-2-yl)phenyl]phenyl}-4H-chromen-4-one | CHEMBL205219 | [4',4''']-biflavone
Type:
Small organic molecule
Emp. Form.:
C30H18O4
Mol. Mass.:
442.4615
SMILES:
O=c1cc(oc2ccccc12)-c1ccc(cc1)-c1ccc(cc1)-c1cc(=O)c2ccccc2o1
Structure:
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