Reaction Details Report a problem with these data
Target
Atrial natriuretic peptide receptor 3
Ligand
BDBM50604564
Substrate
n/a
Meas. Tech.
ChEMBL_2248267 (CHEMBL5162477)
EC50
1430±n/a nM
Citation
 Smith, RJ; Perez-Ternero, C; Conole, D; Martin, C; Myers, SH; Hobbs, AJ; Selwood, DL A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. J Med Chem 65:5495-5513 (2022) [PubMed] 
Target
Name:
Atrial natriuretic peptide receptor 3
Synonyms:
ANP-C | ANPR-C | ANPRC_RAT | Atrial natriuretic peptide clearance receptor | Atrial natriuretic peptide receptor type C | Npr-c | Npr3
Type:
PROTEIN
Mol. Mass.:
59731.56
Organism:
Rattus norvegicus
Description:
ChEMBL_120672
Residue:
535
Sequence:
MRSLLLFTFSACVLLARALLAGGASSGGGDTGPGNRRREREALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALLYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTAKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFKMRSNVKYPWGSLKLRIDETRIVEHTNSSPCKSCGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNHQEESNIGKHRELREDSIRSHFSVA
  
Inhibitor
Name:
BDBM50604564
Synonyms:
CHEMBL5191531
Type:
Small organic molecule
Emp. Form.:
C26H40Cl2N10O4
Mol. Mass.:
627.566
SMILES:
COC(=O)[C@H](CC(C)C)Nc1nc(Cl)nc(N[C@H]2CC[C@@H](CC2)Nc2nc(Cl)nc(N[C@@H](CC(C)C)C(=O)OC)n2)n1 |r,wU:31.31,17.16,wD:20.23,4.8,(7.32,6.16,;5.99,5.39,;6,3.85,;4.66,3.08,;7.32,3.08,;8.66,3.86,;9.99,3.08,;11.33,3.86,;9.99,1.54,;7.33,1.54,;6,.77,;6,-.78,;4.66,-1.55,;4.66,-3.09,;3.33,-.77,;3.34,.77,;2.01,1.53,;.67,.77,;.67,-.77,;-.66,-1.54,;-1.99,-.76,;-2,.78,;-.66,1.54,;-3.31,-1.54,;-4.65,-.76,;-4.65,.79,;-5.99,1.55,;-5.99,3.09,;-7.32,.78,;-7.32,-.76,;-8.66,-1.54,;-8.66,-3.08,;-7.32,-3.84,;-7.32,-5.38,;-5.99,-6.16,;-8.66,-6.16,;-9.99,-3.84,;-9.99,-5.38,;-11.33,-3.08,;-11.33,-1.54,;-5.99,-1.54,;4.67,1.53,)|
Structure:
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