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Target
C-X-C chemokine receptor type 2
Ligand
BDBM50187010
Substrate
n/a
Meas. Tech.
ChEMBL_384848 (CHEMBL867334)
IC50
22±n/a nM
Citation
 Merritt, JR; Rokosz, LL; Nelson, KH; Kaiser, B; Wang, W; Stauffer, TM; Ozgur, LE; Schilling, A; Li, G; Baldwin, JJ; Taveras, AG; Dwyer, MP; Chao, J Synthesis and structure-activity relationships of 3,4-diaminocyclobut-3-ene-1,2-dione CXCR2 antagonists. Bioorg Med Chem Lett 16:4107-10 (2006) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50187010
Synonyms:
3-(3,4-dioxo-2-(phenylamino)cyclobut-1-enylamino)-2-hydroxy-N-methylbenzamide | CHEMBL377397
Type:
Small organic molecule
Emp. Form.:
C18H15N3O4
Mol. Mass.:
337.3294
SMILES:
CNC(=O)c1cccc(Nc2c(Nc3ccccc3)c(=O)c2=O)c1O
Structure:
Search PDB for entries with ligand similarity: