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Target
Estrogen receptor
Ligand
BDBM50190351
Substrate
n/a
Meas. Tech.
ChEMBL_405015 (CHEMBL868058)
IC50
414±n/a nM
Citation
 Wildonger, KJ; Ratcliffe, RW; Mosley, RT; Hammond, ML; Birzin, ET; Rohrer, SP Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands. Bioorg Med Chem Lett 16:4462-6 (2006) [PubMed]  Article 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM50190351
Synonyms:
(1S,12R)-5-hydroxy-10-methyltetracyclo[10.3.1.0^{1,9}.0^{3,8}]hexadeca-3,5,7,9-tetraen-11-one | CHEMBL373987
Type:
Small organic molecule
Emp. Form.:
C17H18O2
Mol. Mass.:
254.3236
SMILES:
CC1=C2c3ccc(O)cc3C[C@@]22CCC[C@H](C2)C1=O |c:1|
Structure:
Search PDB for entries with ligand similarity: