Reaction Details
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NLR family CARD domain-containing protein 4
Ligand
BDBM50607509
Substrate
n/a
Meas. Tech.
ChEMBL_2262823 (CHEMBL5217834)
IC50
>20000±n/a nM
Citation
McBride, C; Trzoss, L; Povero, D; Lazic, M; Ambrus-Aikelin, G; Santini, A; Pranadinata, R; Bain, G; Stansfield, R; Stafford, JA; Veal, J; Takahashi, R; Ly, J; Chen, S; Liu, L; Nespi, M; Blake, R; Katewa, A; Kleinheinz, T; Sujatha-Bhaskar, S; Ramamoorthi, N; Sims, J; McKenzie, B; Chen, M; Ultsch, M; Johnson, M; Murray, J; Ciferri, C; Staben, ST; Townsend, MJ; Stivala, CE Overcoming Preclinical Safety Obstacles to Discover ( J Med Chem 65:14721-14739 (2022) [PubMed] More Info.:
Target
Name:
NLR family CARD domain-containing protein 4
Synonyms:
CARD, LRR, and NACHT-containing protein | CARD12 | CED-4-like protein Clan | CLAN | CLAN GN | CLAN1 | Caspase recruitment domain-containing protein 12 | IPAF | Ice protease-activating factor | NLRC4 | NLRC4_HUMAN | Synonyms=CARD12
Type:
PROTEIN
Mol. Mass.:
116162.30
Organism:
Homo sapiens
Description:
ChEMBL_119950
Residue:
1024
Sequence:
MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILKKGSESCNLFLKSLKEWNYPLFQDLNGQSLFHQTSEGDLDDLAQDLKDLYHTPSFLNFYPLGEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDVLLTTGLLCKYTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNTTEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNWKQEFRTLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFKLVTA
Inhibitor
Name:
BDBM50607509
Synonyms:
CHEMBL5219789
Type:
Small organic molecule
Emp. Form.:
C20H25N5O4S
Mol. Mass.:
431.509
SMILES:
CN[C@@H]1COc2c(cnn2C1)S(=O)(=O)NC(=O)Nc1c2CCCc2cc2CCCc12 |r|
Structure:
