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Target
Acid-sensing ion channel 1
Ligand
BDBM50408492
Substrate
n/a
Meas. Tech.
ChEMBL_2267837
IC50
407±n/a nM
Citation
 Gornati, D; Ciccone, R; Vinciguerra, A; Ippati, S; Pannaccione, A; Petrozziello, T; Pizzi, E; Hassan, A; Colombo, E; Barbini, S; Milani, M; Caccavone, C; Randazzo, P; Muzio, L; Annunziato, L; Menegon, A; Secondo, A; Mastrangelo, E; Pignataro, G; Seneci, P Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult. J Med Chem 64:8333-8353 (2021) [PubMed] 
Target
Name:
Acid-sensing ion channel 1
Synonyms:
ACCN2 | ASIC1 | ASIC1_HUMAN | Acid-sensing ion channel 1 | Amiloride-sensitive cation channel 2, neuronal | BNAC2 | Brain sodium channel 2
Type:
PROTEIN
Mol. Mass.:
59900.27
Organism:
Human
Description:
ChEMBL_1495930
Residue:
528
Sequence:
MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
  
Inhibitor
Name:
BDBM50408492
Synonyms:
CHEMBL5269133
Type:
Small organic molecule
Emp. Form.:
C22H23ClN8
Mol. Mass.:
434.925
SMILES:
Cl.NC(=N)N\N=C\c1ccc(cc1)-c1cccc(c1)-c1ccc(\C=N/NC(N)=N)cc1
Structure:
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