Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50409615
Substrate
n/a
Meas. Tech.
ChEMBL_2268401
Kd
3.8±n/a nM
Citation
 Giordani, A; Menziani, MC; Moresco, RM; Matarrese, M; Paolino, M; Saletti, M; Giuliani, G; Anzini, M; Cappelli, A Exploring Translocator Protein (TSPO) Medicinal Chemistry: An Approach for Targeting Radionuclides and Boron Atoms to Mitochondria. J Med Chem 64:9649-9676 (2021) [PubMed] 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50409615
Synonyms:
CHEMBL5282701
Type:
Small organic molecule
Emp. Form.:
C19H19ClIN3O
Mol. Mass.:
463.732
SMILES:
CCN(CC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc([123I])cc1
Structure:
Search PDB for entries with ligand similarity: