Reaction Details Report a problem with these data
Target
Aquaporin-1
Ligand
BDBM178092
Substrate
n/a
Meas. Tech.
ChEMBL_2271917
IC50
9800±n/a nM
Citation
 Titko, T; Perekhoda, L; Drapak, I; Tsapko, Y Modern trends in diuretics development. Eur J Med Chem 208:0 (2020) [PubMed] 
Target
Name:
Aquaporin-1
Synonyms:
AQP1 | AQP1_HUMAN | Aquaporin-1 (AQP1) | CHIP28
Type:
Protein
Mol. Mass.:
28528.18
Organism:
Human
Description:
n/a
Residue:
269
Sequence:
MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK
  
Inhibitor
Name:
BDBM178092
Synonyms:
{[7-(2,4-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}(methyl)amine (Compound 4)
Type:
Small organic molecule
Emp. Form.:
C16H14Cl2FNO
Mol. Mass.:
326.193
SMILES:
CNCC1Cc2cc(F)cc(c2O1)-c1ccc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: