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Target
Cell division protein FtsZ
Ligand
BDBM50608376
Substrate
n/a
Meas. Tech.
ChEMBL_2273984
IC50
55700±n/a nM
Citation
 Buroni, S; Makarov, V; Scoffone, VC; Trespidi, G; Riccardi, G; Chiarelli, LR The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens. Eur J Med Chem 190:0 (2020) [PubMed] 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_STAAU | ftsZ
Type:
Protein
Mol. Mass.:
41023.36
Organism:
Staphylococcus aureus
Description:
P0A031
Residue:
390
Sequence:
MLEFEQGFNHLATLKVIGVGGGGNNAVNRMIDHGMNNVEFIAINTDGQALNLSKAESKIQIGEKLTRGLGAGANPEIGKKAAEESREQIEDAIQGADMVFVTSGMGGGTGTGAAPVVAKIAKEMGALTVGVVTRPFSFEGRKRQTQAAAGVEAMKAAVDTLIVIPNDRLLDIVDKSTPMMEAFKEADNVLRQGVQGISDLIAVSGEVNLDFADVKTIMSNQGSALMGIGVSSGENRAVEAAKKAISSPLLETSIVGAQGVLMNITGGESLSLFEAQEAADIVQDAADEDVNMIFGTVINPELQDEIVVTVIATGFDDKPTSHGRKSGSTGFGTSVNTSSNATSKDESFTSNSSNAQATDSVSERTHTTKEDDIPSFIRNREERRSRRTRR
  
Inhibitor
Name:
BDBM50608376
Synonyms:
CHEMBL3416822
Type:
Small organic molecule
Emp. Form.:
C27H35N5O
Mol. Mass.:
445.5997
SMILES:
[H][C@@]12CCN(C[C@@H]1c1cc(nc(n1)-c1ccncc1)C(CC)CC)[C@@H](CNCc1ccco1)C2 |r|
Structure:
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