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Target
Cell division protein FtsZ
Ligand
BDBM50320891
Substrate
n/a
Meas. Tech.
ChEMBL_2273984
IC50
37800±n/a nM
Citation
 Buroni, S; Makarov, V; Scoffone, VC; Trespidi, G; Riccardi, G; Chiarelli, LR The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens. Eur J Med Chem 190:0 (2020) [PubMed] 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_STAAU | ftsZ
Type:
Protein
Mol. Mass.:
41023.36
Organism:
Staphylococcus aureus
Description:
P0A031
Residue:
390
Sequence:
MLEFEQGFNHLATLKVIGVGGGGNNAVNRMIDHGMNNVEFIAINTDGQALNLSKAESKIQIGEKLTRGLGAGANPEIGKKAAEESREQIEDAIQGADMVFVTSGMGGGTGTGAAPVVAKIAKEMGALTVGVVTRPFSFEGRKRQTQAAAGVEAMKAAVDTLIVIPNDRLLDIVDKSTPMMEAFKEADNVLRQGVQGISDLIAVSGEVNLDFADVKTIMSNQGSALMGIGVSSGENRAVEAAKKAISSPLLETSIVGAQGVLMNITGGESLSLFEAQEAADIVQDAADEDVNMIFGTVINPELQDEIVVTVIATGFDDKPTSHGRKSGSTGFGTSVNTSSNATSKDESFTSNSSNAQATDSVSERTHTTKEDDIPSFIRNREERRSRRTRR
  
Inhibitor
Name:
BDBM50320891
Synonyms:
9-O-[3-(4-Chloro-phenoxyl)propyl]-berberine bromide | CHEMBL1164137
Type:
Small organic molecule
Emp. Form.:
C28H25ClNO5
Mol. Mass.:
490.954
SMILES:
COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OCCCOc1ccc(Cl)cc1
Structure:
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