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Target
DNA polymerase I, thermostable
Ligand
BDBM50196502
Substrate
n/a
Meas. Tech.
ChEMBL_432004 (CHEMBL918788)
IC50
>40000±n/a nM
Citation
 Sissi, C; Lucatello, L; Paul Krapcho, A; Maloney, DJ; Boxer, MB; Camarasa, MV; Pezzoni, G; Menta, E; Palumbo, M Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition. Bioorg Med Chem 15:555-62 (2006) [PubMed]  Article 
Target
Name:
DNA polymerase I, thermostable
Synonyms:
DNA polymerase I, thermostable | DPO1_THEAQ | Taq polymerase 1 | pol1 | polA
Type:
PROTEIN
Mol. Mass.:
93906.95
Organism:
Thermus aquaticus
Description:
ChEMBL_1289218
Residue:
832
Sequence:
MRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDGDAVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLASLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLKLSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLEFGSLLHEFGLLESPKALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
  
Inhibitor
Name:
BDBM50196502
Synonyms:
2,7-dimethyl-1,2,3,6,7,8-hexahydro-benzo[lmn][3,8]phenanthroline | CHEMBL225312
Type:
Small organic molecule
Emp. Form.:
C16H18N2
Mol. Mass.:
238.3275
SMILES:
CN1Cc2ccc3CN(C)Cc4ccc(C1)c2c34
Structure:
Search PDB for entries with ligand similarity: