Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 7
Ligand
BDBM50609504
Substrate
n/a
Meas. Tech.
ChEMBL_2278032
IC50
7.0±n/a nM
Citation
 Yang, B; Zhang, H; Li, N; Gao, L; Jiang, H; Kan, W; Yuan, H; Li, J; Zhao, D; Xiong, B; Zhou, Y; Guo, D; Liu, T Discovery of Novel  J Med Chem 65:15770-15788 (2022) [PubMed] 
Target
Name:
Cyclin-dependent kinase 7
Synonyms:
39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit
Type:
Enzyme Subunit
Mol. Mass.:
39047.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
346
Sequence:
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
  
Inhibitor
Name:
BDBM50609504
Synonyms:
CHEMBL5274920
Type:
Small organic molecule
Emp. Form.:
C31H27N7O3
Mol. Mass.:
545.5912
SMILES:
N[C@@H](Cc1ccccc1)C(=O)Nc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccc(NC(=O)C=C)cc3)c2c1 |r|
Structure:
Search PDB for entries with ligand similarity: