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Target
Tubulin beta chain
Ligand
BDBM50609720
Substrate
n/a
Meas. Tech.
ChEMBL_2279327
Kd
1700±n/a nM
Citation
 Leng, J; Zhao, Y; Sheng, P; Xia, Y; Chen, T; Zhao, S; Xie, S; Yan, X; Wang, X; Yin, Y; Kong, L Discovery of Novel  J Med Chem 65:16774-16800 (2022) [PubMed] 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Pig
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50609720
Synonyms:
CHEMBL5285469
Type:
Small organic molecule
Emp. Form.:
C20H16Br2N2O5
Mol. Mass.:
524.159
SMILES:
[H][C@@]12Cc3cc4OCCOc4cc3[C@H](N1C(=O)NC2=O)c1cc(Br)c(OC)c(Br)c1 |r|
Structure:
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