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Target
Free fatty acid receptor 4
Ligand
BDBM50609994
Substrate
n/a
Meas. Tech.
ChEMBL_2280112
EC50
1320±n/a nM
Citation
 Lückmann, M; Shenol, A; Nissen, TAD; Petersen, JE; Kouvchinov, D; Schwartz, TW; Frimurer, TM Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action. ACS Med Chem Lett 13:1839-1847 (2022) [PubMed] 
Target
Name:
Free fatty acid receptor 4
Synonyms:
FFAR4 | FFAR4_HUMAN | G-protein coupled receptor 120 | G-protein coupled receptor 129 | G-protein coupled receptor GT01 | G-protein coupled receptor PGR4 | GPR120 | GPR129 | O3FAR1 | Omega-3 fatty acid receptor 1 | PGR4 | Synonyms=GPR120
Type:
PROTEIN
Mol. Mass.:
40511.04
Organism:
Homo sapiens
Description:
ChEMBL_100956
Residue:
361
Sequence:
MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
  
Inhibitor
Name:
BDBM50609994
Synonyms:
CHEMBL5272492
Type:
Small organic molecule
Emp. Form.:
C22H21N5O3
Mol. Mass.:
403.4338
SMILES:
CCc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C)cc4)n3)ccc12
Structure:
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