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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50197448
Substrate
n/a
Meas. Tech.
ChEMBL_432257 (CHEMBL914035)
IC50
4000±n/a nM
Citation
 Pham-Huu, DP; Deschamps, JR; Liu, S; Madras, BK; Meltzer, PC Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. Bioorg Med Chem 15:1067-82 (2006) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
SC6A4_MACMU | SLC6A4 | Serotonin transporter
Type:
PROTEIN
Mol. Mass.:
70256.94
Organism:
Macaca mulatta
Description:
ChEMBL_432257
Residue:
630
Sequence:
METTPLNSQKQLSACKDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPAATTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSFVCIPTYIAYRLISTPGTFKERIIKSITPETPTEIPCGDVRLNAV
  
Inhibitor
Name:
BDBM50197448
Synonyms:
(1S)-2-carbomethoxy-3-(3,4-dichlorophenyl)-8-thiabicyclo[3.2.1]-2-octene | CHEMBL388300
Type:
Small organic molecule
Emp. Form.:
C15H14Cl2O2S
Mol. Mass.:
329.241
SMILES:
COC(=O)C1=C(CC2CC[C@@H]1S2)c1ccc(Cl)c(Cl)c1 |t:4,TLB:12:5:11:9.8,THB:2:4:11:9.8|
Structure:
Search PDB for entries with ligand similarity: