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Target
Metallo-beta-lactamase type 2
Ligand
BDBM50339145
Substrate
n/a
Meas. Tech.
ChEMBL_2299200
IC50
141±n/a nM
Citation
 Kumar, R; Pathania, V; Kumar, S; Kumar, M; Nandanwar, H; Maurya, SK Synthesis of novel ciprofloxacin-avibactam conjugates for the development of second-generation non-?-lactam-?-lactamase inhibitors. Bioorg Med Chem Lett 88:0 (2023) [PubMed] 
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
BLAB_BACCE | Beta-lactamase 2 | Metallo-beta-lactamase domain-containing protein 2 | Metallo-beta-lactamase superfamily protein
Type:
PROTEIN
Mol. Mass.:
28044.00
Organism:
Bacillus cereus
Description:
ChEMBL_104097
Residue:
256
Sequence:
MKNTLLKLGVCVSLLGITPFVSTISSVQAERTVEHKVIKNETGTISISQLNKNVWVHTELGYFSGEAVPSNGLVLNTSKGLVLVDSSWDDKLTKELIEMVEKKFKKRVTDVIITHAHADRIGGMKTLKERGIKAHSTALTAELAKKNGYEEPLGDLQSVTNLKFGNMKVETFYPGKGHTEDNIVVWLPQYQILAGGCLVKSASSKDLGNVADAYVNEWSTSIENVLKRYGNINLVVPGHGEVGDRGLLLHTLDLLK
  
Inhibitor
Name:
BDBM50339145
Synonyms:
CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octan-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C7H11N3O6S
Mol. Mass.:
265.244
SMILES:
NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(O)(=O)=O |r|
Structure:
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