Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM50209744
Substrate
n/a
Meas. Tech.
ChEMBL_434361 (CHEMBL919420)
IC50
0.8±n/a nM
Citation
Biswas, K; Li, A; Chen, JJ; D'Amico, DC; Fotsch, C; Han, N; Human, J; Liu, Q; Norman, MH; Riahi, B; Yuan, C; Suzuki, H; Mareska, DA; Zhan, J; Clarke, DE; Toro, A; Groneberg, RD; Burgess, LE; Lester-Zeiner, D; Biddlecome, G; Manning, BH; Arik, L; Dong, H; Huang, M; Kamassah, A; Loeloff, R; Sun, H; Hsieh, FY; Kumar, G; Ng, GY; Hungate, RW; Askew, BC; Johnson, E Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides. J Med Chem 50:2200-12 (2007) [PubMed] Article
More Info.:
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Human
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Inhibitor
Name:
BDBM50209744
Synonyms:
(R)-3-(4-fluorophenyl)-N-((R)-7-(piperidin-1-ylmethyl)-3,4-dihydro-2H-chromen-4-yl)-3-(3-(trifluoromethyl)phenylsulfonamido)propanamide | (R)-3-(4-fluorophenyl)-N-((R)-7-(piperidin-1-ylmethyl)chroman-4-yl)-3-(3-(trifluoromethyl)phenylsulfonamido)-propanamide | CHEMBL227713
Type:
Small organic molecule
Emp. Form.:
C31H33F4N3O4S
Mol. Mass.:
619.67
SMILES:
Fc1ccc(cc1)[C@@H](CC(=O)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc12)NS(=O)(=O)c1cccc(c1)C(F)(F)F |r|