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Target
Diacylglycerol lipase-alpha
Ligand
BDBM50242637
Substrate
n/a
Meas. Tech.
ChEMBL_530430 (CHEMBL972195)
IC50
600±n/a nM
Citation
 Ortar, G; Cascio, MG; Moriello, AS; Camalli, M; Morera, E; Nalli, M; Di Marzo, V Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. Eur J Med Chem 43:62-72 (2008) [PubMed]  Article 
Target
Name:
Diacylglycerol lipase-alpha
Synonyms:
C11orf11 | DAGLA | DGLA_HUMAN | KIAA0659 | NSDDR | Sn1-specific diacylglycerol lipase alpha
Type:
PROTEIN
Mol. Mass.:
114947.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1449471
Residue:
1042
Sequence:
MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFALAAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRNSSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIRTSTPTGHGASPAKQDELVISAR
  
Inhibitor
Name:
BDBM50242637
Synonyms:
CHEMBL504374 | N,N-dimethyl-5-phenethyl-2H-tetrazole-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C12H15N5O
Mol. Mass.:
245.2804
SMILES:
CN(C)C(=O)n1nnc(CCc2ccccc2)n1
Structure:
Search PDB for entries with ligand similarity: