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Target
Cruzipain
Ligand
BDBM50243051
Substrate
n/a
Meas. Tech.
ChEMBL_491590 (CHEMBL944236)
IC50
32000±n/a nM
Citation
 Porcal, W; Hernández, P; Boiani, L; Boiani, M; Ferreira, A; Chidichimo, A; Cazzulo, JJ; Olea-Azar, C; González, M; Cerecetto, H New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle. Bioorg Med Chem 16:6995-7004 (2008) [PubMed]  Article 
Target
Name:
Cruzipain
Synonyms:
CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase
Type:
Protein
Mol. Mass.:
49831.41
Organism:
Trypanosoma cruzi
Description:
P25779
Residue:
467
Sequence:
MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSYFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
  
Inhibitor
Name:
BDBM50243051
Synonyms:
4-(Benzofuroxan-5-ylmethyloxy)benzaldehydeamidinohydrazone | CHEMBL512308
Type:
Small organic molecule
Emp. Form.:
C15H14N6O3
Mol. Mass.:
326.3101
SMILES:
NC([NH-])=[NH+]N=Cc1ccc(OCc2ccc3no[n+]([O-])c3c2)cc1 |w:5.5,3.3|
Structure:
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