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Target
Low molecular weight protein-tyrosine phosphatase A
Ligand
BDBM50246311
Substrate
n/a
Meas. Tech.
ChEMBL_558024 (CHEMBL953321)
IC50
53700±n/a nM
Citation
 Chiaradia, LD; Mascarello, A; Purificação, M; Vernal, J; Cordeiro, MN; Zenteno, ME; Villarino, A; Nunes, RJ; Yunes, RA; Terenzi, H Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Bioorg Med Chem Lett 18:6227-30 (2008) [PubMed]  Article 
Target
Name:
Low molecular weight protein-tyrosine phosphatase A
Synonyms:
PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA
Type:
Hydrolase
Mol. Mass.:
17891.84
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
163
Sequence:
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
  
Inhibitor
Name:
BDBM50246311
Synonyms:
(2E)-1-(3'-methoxy-4'-hydroxyphenyl)-3-(2-naphthyl)-2-propen-1-one | CHEMBL520906
Type:
Small organic molecule
Emp. Form.:
C20H18O3
Mol. Mass.:
306.3551
SMILES:
COC1C=C(C=CC1O)C(=O)\C=C\c1ccc2ccccc2c1 |c:3,5|
Structure:
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