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Target
Low molecular weight protein-tyrosine phosphatase A
Ligand
BDBM50246224
Substrate
n/a
Meas. Tech.
ChEMBL_558024 (CHEMBL953321)
IC50
50700±n/a nM
Citation
 Chiaradia, LD; Mascarello, A; Purificação, M; Vernal, J; Cordeiro, MN; Zenteno, ME; Villarino, A; Nunes, RJ; Yunes, RA; Terenzi, H Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Bioorg Med Chem Lett 18:6227-30 (2008) [PubMed]  Article 
Target
Name:
Low molecular weight protein-tyrosine phosphatase A
Synonyms:
PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA
Type:
Hydrolase
Mol. Mass.:
17891.84
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
163
Sequence:
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
  
Inhibitor
Name:
BDBM50246224
Synonyms:
(2E)-1-(2'-Hydroxyphenyl)-3-(1-naphtyl)-2-propen-1-one | (2E)-1-(2'-hydroxyphenyl)-3-(1-naphthyl)-2-propen-1-one | 1-(2'-hydroxyphenyl)-3-(1-naphthyl)-2-propen-1-one | CHEMBL487051
Type:
Small organic molecule
Emp. Form.:
C19H14O2
Mol. Mass.:
274.3133
SMILES:
Oc1ccccc1C(=O)\C=C\c1cccc2ccccc12
Structure:
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