Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50273862
Substrate
n/a
Meas. Tech.
ChEMBL_561233 (CHEMBL1013588)
IC50
5±n/a nM
Citation
 Fotsch, C; Bartberger, MD; Bercot, EA; Chen, M; Cupples, R; Emery, M; Fretland, J; Guram, A; Hale, C; Han, N; Hickman, D; Hungate, RW; Hayashi, M; Komorowski, R; Liu, Q; Matsumoto, G; St Jean, DJ; Ursu, S; Véniant, M; Xu, G; Ye, Q; Yuan, C; Zhang, J; Zhang, X; Tu, H; Wang, M Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model. J Med Chem 51:7953-67 (2008) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50273862
Synonyms:
CHEMBL462305 | N-(5-Hydroxy-adamantan-2-yl)-2-m-tolyl-isobutyramide
Type:
Small organic molecule
Emp. Form.:
C21H29NO2
Mol. Mass.:
327.4605
SMILES:
Cc1cccc(c1)C(C)(C)C(=O)NC1C2CC3CC1CC(O)(C3)C2 |TLB:13:14:22:17.18.19,12:13:22.16.17:19,THB:15:16:19:23.14.13,15:14:22.16.17:19,13:18:22:23.15.14,(4.42,-45.81,;3.07,-45.05,;3.06,-43.51,;1.71,-42.76,;.39,-43.55,;.41,-45.07,;1.75,-45.84,;-.91,-45.86,;-.13,-47.19,;-1.69,-44.53,;-2.24,-46.63,;-2.24,-48.17,;-3.58,-45.87,;-4.91,-46.64,;-5.01,-48.17,;-6.1,-49.38,;-7.47,-48.74,;-7.39,-47.15,;-6.27,-45.98,;-7.65,-46.38,;-7.73,-47.86,;-9.2,-47.36,;-9,-49.07,;-6.43,-48.43,)|
Structure:
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