Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50248388
Substrate
n/a
Meas. Tech.
ChEMBL_565879 (CHEMBL959302)
EC50
200±n/a nM
Citation
 Nishimura, T; Iino, T; Mitsuya, M; Bamba, M; Watanabe, H; Tsukahara, D; Kamata, K; Sasaki, K; Ohyama, S; Hosaka, H; Futamura, M; Nagata, Y; Eiki, J Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators. Bioorg Med Chem Lett 19:1357-60 (2009) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50248388
Synonyms:
2-amino-N-(4-methylthiazol-2-yl)-5-(phenylthio)benzamide | CHEMBL489333
Type:
Small organic molecule
Emp. Form.:
C17H15N3OS2
Mol. Mass.:
341.451
SMILES:
Cc1csc(NC(=O)c2cc(Sc3ccccc3)ccc2N)n1
Structure:
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