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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50280995
Substrate
n/a
Meas. Tech.
ChEBML_201267
IC50
6±n/a nM
Citation
 Reddy, NL; Fischer, JB; Burke-Howie, KJ; Barmettler, P; Rhodes, MR; Weber, E; Keana, JF N,N′-disubstituted acetamidines as high affinity sigma receptor ligands Bioorg Med Chem Lett 3:2113-2116 (1993)    Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50280995
Synonyms:
CHEMBL542638 | N-Adamantan-1-yl-N'-o-tolyl-acetamidine; hydrochloride
Type:
Small organic molecule
Emp. Form.:
C19H26N2
Mol. Mass.:
282.4231
SMILES:
CC(NC12CC3CC(CC(C3)C1)C2)=Nc1ccccc1C |w:13.16,TLB:2:3:10:7.6.8,2:3:5.6.10:8,12:3:10:7.6.8,THB:4:3:5.6.10:8,4:5:3.12.11:8,12:7:3.4.11:10|
Structure:
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