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Target
Interstitial collagenase
Ligand
BDBM50285721
Substrate
n/a
Meas. Tech.
ChEBML_101737
IC50
510±n/a nM
Citation
 Bird, J; Harper, GP; Hughes, I; Hunter, DJ; Karran, EH; Markwell, RE; Miles-Williams, AJ; Rahman, SS; Ward, RW Inhibitors of human collagenase: dipeptide mimetics with lactam and azalactam moieties at the P2′/P3′ position Bioorg Med Chem Lett 5:2593-2598 (1995)    Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50285721
Synonyms:
CHEMBL3142563 | CHEMBL424239 | {(R)-1-[3-Methyl-1-(8-oxo-1,7diaza-cyclotridec-9-ylcarbamoyl)-butylamino]-propyl}-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C21H43N4O5P
Mol. Mass.:
462.5637
SMILES:
CC[C@H](N[C@@H](CC(C)C)C(=O)NC1CCCCN(C)CCCCCNC1=O)P(O)(O)=O
Structure:
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