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Target
G-protein coupled receptor homolog US28
Ligand
BDBM50027205
Substrate
n/a
Meas. Tech.
ChEMBL_321572 (CHEMBL881787)
IC50
72400±n/a nM
Citation
 Hulshof, JW; Casarosa, P; Menge, WM; Kuusisto, LM; van der Goot, H; Smit, MJ; de Esch, IJ; Leurs, R Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28. J Med Chem 48:6461-71 (2005) [PubMed]  Article 
Target
Name:
G-protein coupled receptor homolog US28
Synonyms:
Human herpesvirus 5 chemokine receptor | US28 | US28_HCMVA
Type:
PROTEIN
Mol. Mass.:
41070.46
Organism:
HHV-5
Description:
ChEMBL_322135
Residue:
354
Sequence:
MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
  
Inhibitor
Name:
BDBM50027205
Synonyms:
5-[4-Hydroxy-4-(4-methoxy-phenyl)-piperidin-1-yl]-2,2-diphenyl-pentanenitrile | CHEMBL141713
Type:
Small organic molecule
Emp. Form.:
C29H32N2O2
Mol. Mass.:
440.5766
SMILES:
COc1ccc(cc1)C1(O)CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1
Structure:
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