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Target
G-protein coupled receptor homolog US28
Ligand
BDBM50027219
Substrate
n/a
Meas. Tech.
ChEMBL_322135 (CHEMBL885194)
EC50
28200±n/a nM
Citation
 Hulshof, JW; Casarosa, P; Menge, WM; Kuusisto, LM; van der Goot, H; Smit, MJ; de Esch, IJ; Leurs, R Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28. J Med Chem 48:6461-71 (2005) [PubMed]  Article 
Target
Name:
G-protein coupled receptor homolog US28
Synonyms:
Human herpesvirus 5 chemokine receptor | US28 | US28_HCMVA
Type:
PROTEIN
Mol. Mass.:
41070.46
Organism:
HHV-5
Description:
ChEMBL_322135
Residue:
354
Sequence:
MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
  
Inhibitor
Name:
BDBM50027219
Synonyms:
5-(4-Hydroxy-4-phenyl-piperidin-1-yl)-2,2-diphenyl-pentanenitrile | CHEMBL195943
Type:
Small organic molecule
Emp. Form.:
C28H30N2O
Mol. Mass.:
410.5506
SMILES:
OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccccc1
Structure:
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