Reaction Details Report a problem with these data
Target
Cytochrome P450 2J2
Ligand
BDBM50297400
Substrate
n/a
Meas. Tech.
ChEMBL_582800 (CHEMBL1058985)
IC50
3000±n/a nM
Citation
 Eldrup, AB; Soleymanzadeh, F; Taylor, SJ; Muegge, I; Farrow, NA; Joseph, D; McKellop, K; Man, CC; Kukulka, A; De Lombaert, S Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J Med Chem 52:5880-95 (2009) [PubMed]  Article 
Target
Name:
Cytochrome P450 2J2
Synonyms:
CP2J2_HUMAN | CYP2J2
Type:
Enzyme
Mol. Mass.:
57623.04
Organism:
Human
Description:
P51589
Residue:
502
Sequence:
MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVPQV
  
Inhibitor
Name:
BDBM50297400
Synonyms:
(S)-4-Cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulfonyl-phenyl)-propyl]-benzamide | 4-cyano-N-{(3S)-3-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}benzamide | CHEMBL556717
Type:
Small organic molecule
Emp. Form.:
C24H21FN2O3S
Mol. Mass.:
436.499
SMILES:
CS(=O)(=O)c1ccc(cc1)[C@@H](CCNC(=O)c1ccc(cc1)C#N)c1ccc(F)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: