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Target
Cyclin-dependent kinase 5
Ligand
BDBM50299869
Substrate
n/a
Meas. Tech.
ChEMBL_590066 (CHEMBL1043895)
IC50
131±n/a nM
Citation
 Kaller, MR; Zhong, W; Henley, C; Magal, E; Nguyen, T; Powers, D; Rzasa, RM; Wang, W; Xiong, X; Norman, MH Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors. Bioorg Med Chem Lett 19:6591-4 (2009) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5
Synonyms:
CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Inhibitor
Name:
BDBM50299869
Synonyms:
CHEMBL577030 | ethyl 2-methyl-6-oxo-5-(2-(pyridin-4-yl)thiazol-4-yl)-1,6-dihydropyridine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H15N3O3S
Mol. Mass.:
341.384
SMILES:
CCOC(=O)c1cc(-c2csc(n2)-c2ccncc2)c(=O)[nH]c1C
Structure:
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