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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM50300547
Substrate
n/a
Meas. Tech.
ChEMBL_588743 (CHEMBL1053690)
IC50
8000±n/a nM
Citation
 Beausoleil, E; Chauvignac, C; Taverne, T; Lacombe, S; Pognante, L; Leblond, B; Pallares, D; Oliveira, CD; Bachelot, F; Carton, R; Peillon, H; Coutadeur, S; Picard, V; Lambeng, N; Désiré, L; Schweighoffer, F Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding. Bioorg Med Chem Lett 19:5594-8 (2009) [PubMed]  Article 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1 | RAC1_HUMAN | Ras-related C3 botulinum toxin substrate 1 | Ras-related C3 botulinum toxin substrate 1/T-lymphoma invasion and metastasis-inducing protein 1 | TC25
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1337921
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM50300547
Synonyms:
2,3,9,10-Tetrahydroxy-5,6-dihydro-isoquino[3,2-a]isoquinolinylium chloride | CHEMBL572918
Type:
Small organic molecule
Emp. Form.:
C17H14NO4
Mol. Mass.:
296.2968
SMILES:
Oc1cc2CCn3cc4c(ccc(O)c4=[OH+])cc3-c2cc1O
Structure:
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