Reaction Details Report a problem with these data
Target
Thyroid hormone receptor alpha
Ligand
BDBM50304777
Substrate
n/a
Meas. Tech.
ChEMBL_605572 (CHEMBL1068515)
Ki
0.7±n/a nM
Citation
 Li, JJ; Mitchell, LH; Dow, RL Thyroid receptor agonists for the treatment of androgenetic alopecia. Bioorg Med Chem Lett 20:306-8 (2010) [PubMed]  Article 
Target
Name:
Thyroid hormone receptor alpha
Synonyms:
C-erbA-alpha | EAR-7 | EAR7 | ERBA1 | NR1A1 | Nuclear receptor subfamily 1 group A member 1 | THA_HUMAN | THRA | THRA1 | THRA2 | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor | Thyroid hormone receptor alpha | Thyroid hormone receptor apha | c-erbA-1
Type:
Receptor
Mol. Mass.:
54818.00
Organism:
Human
Description:
Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRalpha 1.
Residue:
490
Sequence:
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVCEDLAGNAASP
  
Inhibitor
Name:
BDBM50304777
Synonyms:
2-(4-(7-hydroxy-2,3-dihydro-1H-inden-4-yloxy)-3,5-dimethylphenylamino)-2-oxoacetic acid | CHEMBL608990
Type:
Small organic molecule
Emp. Form.:
C19H19NO5
Mol. Mass.:
341.3579
SMILES:
Cc1cc(NC(=O)C(O)=O)cc(C)c1Oc1ccc(O)c2CCCc12
Structure:
Search PDB for entries with ligand similarity: