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Target
Beta-2 adrenergic receptor
Ligand
BDBM50306802
Substrate
n/a
Meas. Tech.
ChEMBL_611947 (CHEMBL1071508)
EC50
1.4±n/a nM
Citation
 Bouyssou, T; Hoenke, C; Rudolf, K; Lustenberger, P; Pestel, S; Sieger, P; Lotz, R; Heine, C; Büttner, FH; Schnapp, A; Konetzki, I Discovery of olodaterol, a novel inhaled beta2-adrenoceptor agonist with a 24 h bronchodilatory efficacy. Bioorg Med Chem Lett 20:1410-4 (2010) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50306802
Synonyms:
CHEMBL600617 | rac-6-hydroxy-8-(1-hydroxy-2-(2-methyl-1-(2-(trifluoromethyl)phenyl)propan-2-ylamino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
Type:
Small organic molecule
Emp. Form.:
C21H23F3N2O4
Mol. Mass.:
424.4135
SMILES:
CC(C)(Cc1ccccc1C(F)(F)F)NCC(O)c1cc(O)cc2NC(=O)COc12
Structure:
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